BDBM50340002 2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fluorobenzonitrile oxalate::CHEMBL1762479

SMILES NCC[C@@H](Oc1cc(Cl)c(F)cc1C#N)c1ccccc1

InChI Key InChIKey=BOQFUQUDOGMCLR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340002   

TargetSodium-dependent noradrenaline transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 340nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 700nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340002(2-[[(1R)-3-Amino-1-phenylpropyl]oxy]-4-chloro-5-fl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed