BDBM50340003 (R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotinonitrile fumarate::CHEMBL1762480

SMILES Cc1ccc(C#N)c(S[C@H](CCN)c2ccccc2)n1

InChI Key InChIKey=LDAUFMYFIINTDH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340003   

TargetSodium-dependent noradrenaline transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 600nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed