BDBM50340017 4-((5-(4-chlorobenzylthio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)methyl)-6-(trifluoromethyl)-2H-benzo[b][1,4]thiazin-3(4H)-one::CHEMBL1762486

SMILES FC(F)(F)c1ccc2SCC(=O)N(Cc3nnc(SCc4ccc(Cl)cc4)n3C3CC3)c2c1

InChI Key InChIKey=UTFOHALOGSFHFZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340017   

TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340017(4-((5-(4-chlorobenzylthio)-4-cyclopropyl-4H-1,2,4-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340017(4-((5-(4-chlorobenzylthio)-4-cyclopropyl-4H-1,2,4-...)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed