BDBM50340099 2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-indol-3-yl)thiazol-4-yl)methyl)(isopropyl)amino)ethanol::CHEMBL1762808

SMILES CC(C)N(CCO)Cc1csc(n1)-c1cn(CC2CCOCC2)c2c(Cl)cccc12

InChI Key InChIKey=VCUDJYYRRWZBSA-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50340099   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP1A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 9.78E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2E1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 using 7-benzyloxyquinoline as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340099(2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 using dibenzylfluorescein as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed