BDBM50340302 CHEMBL1760776::N-((S)-3-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,7-diazaspiro[4.5]decan-7-yl)-2-hydroxypropyl)-3,5-dimethylisoxazole-4-sulfonamide

SMILES Cc1noc(C)c1S(=O)(=O)NC[C@@H](O)CN1CCC[C@@]2(CCN(C2)c2ncnc(N)c2C2CC2)C1

InChI Key InChIKey=VWAPTRBPESSVKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340302   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50340302(N-((S)-3-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50340302(N-((S)-3-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-...)
Affinity DataIC50: 490nMAssay Description:Inhibition of AKT1-mediated PRAS40 phosphorylation in human LNCaP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed