BDBM50340502 CHEMBL1762178::N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylthio)phenyl)imidazolidin-1-yl)methyl)pyridin-2-yl)acetamide

SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1

InChI Key InChIKey=JXIZWVBNXZXRKO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340502   

TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 28nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 175nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed