BDBM50340526 (S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione::CHEMBL1762346

SMILES FCCOc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CC[C@H]2COc2ccccc2)cc1

InChI Key InChIKey=TYGQNSUHNPKJOA-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340526   

TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataIC50: 26.1nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340526((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymeth...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed