BDBM50340555 (4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpholinophenylamino)pyrimidin-4-yl)amino)phenyl)methanol::CHEMBL1762546

SMILES Cc1ccc(cc1N(C)c2ccnc(n2)Nc3cc(cc(c3)S(=O)(=O)C)N4CCOCC4)CO

InChI Key InChIKey=IVWHSTCJCURGMH-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340555   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340555((4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpho...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340555((4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpho...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340555((4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpho...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340555((4-methyl-3-(methyl(2-(3-(methylsulfonyl)-5-morpho...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PAK1 phosphorylation in human MCF10A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)