BDBM50340660 CHEMBL1762210::rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-ethyl oxime

SMILES CCO\N=C1/C(O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(C)c[nH]c12

InChI Key InChIKey=NMIXBOUDRDWICA-UHFFFAOYSA-N

Data  4 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340660   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataIC50: 5.20nMAssay Description:Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataIC50: 2.60nMAssay Description:Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataEC50:  115nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  0.600nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  27nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  430nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed