BDBM50340661 CHEMBL1760023::rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-methyl oxime

SMILES CO\N=C1/C(O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(C)c[nH]c12

InChI Key InChIKey=IDOKWANEHDNOLY-UHFFFAOYSA-N

Data  4 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340661   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataIC50: 17nMAssay Description:Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataIC50: 3.40nMAssay Description:Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataEC50:  560nMAssay Description:Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  3.80nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340661(rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methy...)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed