BDBM50340802 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorophenyl)pyrazine::CHEMBL1760805

SMILES Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1F)-c1cnccn1

InChI Key InChIKey=PLKKSSJPSJWGPI-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340802   

LigandPNGBDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340802(2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed