BDBM50340923 CHEMBL1761929::Methyl {4-[6,7-dimethoxy-quinazolin-4-ylamino]phenyl}carbamate (11b)::methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenylcarbamate

SMILES COC(=O)Nc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1

InChI Key InChIKey=HNEAOQOOUVUUJR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340923   

TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 5.79E+3nMAssay Description:Inhibition of N-terminal human recombinant VEGFR-2 by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 6.87E+3nMAssay Description:Inhibition of EGFR (unknown origin) expressed in baculovirus system by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 7.24E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50340923(methyl 4-(6,7-dimethoxyquinazolin-4-ylamino)phenyl...)
Affinity DataIC50: 7.98E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed