BDBM50340952 4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl)-N,N-dimethylpiperidine-1-carboxamide::CHEMBL1762114

SMILES CN(C)C(=O)N1CCC(CC1)c1nc(-c2cc3ccccc3[nH]2)c2c(N)nccn12

InChI Key InChIKey=AMCOPXBOIWZWHG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50340952   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 770nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50340952(4-(8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed