BDBM50341308 CHEMBL1766021::N-methyl-3-aminothiazolo-morphinan::US10766864, Example 115

SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1cc2sc(N)nc2cc31

InChI Key InChIKey=MFCKRIRSBAZCHR-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341308   

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341308(N-methyl-3-aminothiazolo-morphinan | CHEMBL1766021...)
Affinity DataKi:  1.10nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341308(N-methyl-3-aminothiazolo-morphinan | CHEMBL1766021...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341308(N-methyl-3-aminothiazolo-morphinan | CHEMBL1766021...)
Affinity DataIC50: 55nMAssay Description:Affinities of various compounds were measured in vitro using competitive radioligand binding assays. Serial dilutions of test compounds were incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341308(N-methyl-3-aminothiazolo-morphinan | CHEMBL1766021...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed