BDBM50341520 3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl)-(1H)-pyridin-2-one::CHEMBL1765097

SMILES c1cc(ccc1C(=O)NC2=CC(=CNC2=O)c3ccncc3)N4CCCCC4

InChI Key InChIKey=ABBVAIMDGQMDHS-UHFFFAOYSA-N

Data  7 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341520   

TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  12nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  32nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  93nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of full length N-terminal His-tagged Aurora A (unknown origin) using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of full length human Mps1 using fluorescence-labeled H236 peptide as substrate after 60 to 90 mins in presence of ATP by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B/Inner centromere protein(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed