BDBM50341529 (S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)benzoylamino)-5-(3-cyano-5-(methylamino)phenyl)-(1H)-pyridin-2-one::CHEMBL1765784

SMILES CNc1cc(cc(c1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1)C#N

InChI Key InChIKey=WQFCZTFEEFAYIY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341529   

TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341529((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of Itk after 40 mins by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341529((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  400nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341529((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  410nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341529((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi:  480nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed