BDBM50341712 3-amino-N,6-diphenylpyrazine-2-carboxamide::CHEMBL1766759::US10479784, Compound I-15::US10961232, Compound I-15

SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1

InChI Key InChIKey=RNMJNHVCCXRKJE-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50341712   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 620nMAssay Description:Competitive inhibition of DNA-PKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as hydroxyurea-induced phosphorylation of H2AX by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 620nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataKi:  2.55E+3nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341712(3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMB...)
Affinity DataKi:  5.05E+3nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
Go to US Patent