BDBM50341719 3-amino-6-(2-cyanophenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766765

SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1C#N

InChI Key InChIKey=YFHBYQHMVTVHDA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341719   

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341719(3-amino-6-(2-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 24nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341719(3-amino-6-(2-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 320nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341719(3-amino-6-(2-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 720nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed