BDBM50341732 3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766778::US10479784, Compound I-21::US10961232, Compound I-21

SMILES Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccc(cc1)C#N

InChI Key InChIKey=XEKZYYNYWYIVQD-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50341732   

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341732(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341732(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50341732(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 180nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341732(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341732(3-amino-6-(4-cyanophenyl)-N-phenylpyrazine-2-carbo...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed