BDBM50341745 3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyrazine-2-carboxamide::CHEMBL1766791

SMILES CS(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1

InChI Key InChIKey=XKSHJVRSLGTDOV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341745   

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341745(3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 56nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341745(3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as hydroxyurea-induced phosphorylation of H2AX by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341745(3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341745(3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyraz...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed