BDBM50341755 3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)phenyl)-pyrazin-2-amine::CHEMBL1766801::US10479784, Compound I-123::US10961232, Compound I-123

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1nc2ccccc2[nH]1

InChI Key InChIKey=NVZFTEWCKUYXCM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50341755   

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341755(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Affinity DataIC50: 30nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341755(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341755(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2020
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341755(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Affinity DataIC50: 380nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341755(3-(1H-benzo[d]imidazol-2-yl)-5-(4-(methylsulfonyl)...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed