BDBM50342544 2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine::CHEMBL1770385

SMILES FC(F)(F)c1cccc(Cc2ncc3CCNCCc3n2)c1

InChI Key InChIKey=VSAKTLIDVOIELQ-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342544   

Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342544(2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342544(2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342544(2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5...)
Affinity DataKi:  308nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed