BDBM50343195 CHEMBL1773582::N-(6-(2-(4-Methyl-N-methylphenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=CJVXPWZJWZDNTG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343195   

LigandPNGBDBM50343195(N-(6-(2-(4-Methyl-N-methylphenylsulfonamido)pyrimi...)
Affinity DataIC50: 334nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343195(N-(6-(2-(4-Methyl-N-methylphenylsulfonamido)pyrimi...)
Affinity DataIC50: 269nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343195(N-(6-(2-(4-Methyl-N-methylphenylsulfonamido)pyrimi...)
Affinity DataKi:  38nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed