BDBM50343202 CHEMBL1773603::N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

SMILES COc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1C)-c1ccc2nc(NC(C)=O)sc2c1

InChI Key InChIKey=MKGZBKFXWSPUTF-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343202   

LigandPNGBDBM50343202(N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyrid...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343202(N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyrid...)
Affinity DataIC50: 6nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343202(N-(6-(5-(4-Methoxyphenylsulfonamido)-6-methylpyrid...)
Affinity DataIC50: 18nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed