BDBM50343489 CHEMBL1773502::N-Cyclohexyl-4-(4-(4-fluorophenyl)-2-(isopropylthio)-1Himidazol-5-yl)pyridin-2-amine

SMILES CC(C)Sc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC2CCCCC2)c1

InChI Key InChIKey=KAKPVALXSVEUNX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343489   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343489(N-Cyclohexyl-4-(4-(4-fluorophenyl)-2-(isopropylthi...)
Affinity DataIC50: 650nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50343489(N-Cyclohexyl-4-(4-(4-fluorophenyl)-2-(isopropylthi...)
Affinity DataIC50: 12nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed