BDBM50343724 (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-isopropoxy-1H-pyrazol-3-ylamino)nicotinonitrile::CHEMBL1774054

SMILES CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)c(cc2F)C#N)[nH]n1

InChI Key InChIKey=QRAQXWWNHQMCBH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343724   

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343724((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: 688nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343724((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed