BDBM50344260 CHEMBL1779013::N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methyl)picolinamide

SMILES COc1cc(F)ccc1-c1cncc(CNC(=O)c2ccccn2)c1

InChI Key InChIKey=XEKZQVZQOZRWEJ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50344260   

TargetCytochrome P450 2D6(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Iinhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Iinhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells electrophysiology studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataIC50: 673nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells assessed as glutamate-induced changes in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344260(N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methy...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed