BDBM50344662 8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile::CHEMBL1779200::US9126931, 90

SMILES CC(C)N1CCN(CC1)c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2c1

InChI Key InChIKey=OJAQYCZSPRPJGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344662   

TargetALK tyrosine kinase receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344662(8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344662(8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-...)
Affinity DataIC50: 33.6nMAssay Description:ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent