BDBM50349099 CHEMBL1808338

SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21

InChI Key InChIKey=ZWRLLBAFCKACAL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50349099   

TargetDual specificity protein kinase TTK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349099(CHEMBL1808338)
Affinity DataIC50: 36nMAssay Description:Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349099(CHEMBL1808338)
Affinity DataIC50: 768nMAssay Description:Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349099(CHEMBL1808338)
Affinity DataIC50: 3.03E+3nMAssay Description:Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50349099(CHEMBL1808338)
Affinity DataIC50: 5.57E+3nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed