BDBM50350396 CHEMBL1573436

SMILES CC(=O)NC(c1cccs1)c1cc(Br)c2cccnc2c1O

InChI Key InChIKey=FREDZQWTOHKXRX-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50350396   

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of 12-lipoxygenase in human platelets assessed as reduction of PAR1-AP-induced 12 HETE production by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-1 assessed as conjugated diene product formation using arachidonic acid by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 5-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Mouse)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of mouse N-terminally His6-tagged 12-lipoxygenase expressed in SF9 insect cells assessed as 12-HPETE formation using arachidonic acid by U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Mouse)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of mouse N-terminally His6-tagged 15-lipoxygenase expressed in SF9 insect cells assessed as 15-HPETE formation using arachidonic acid by U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 5-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-1 assessed as conjugated diene product formation using arachidonic acid by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50350396(CHEMBL1573436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human reticulocyte N-terminally His6-tagged 15-lipoxygenase-2 assessed as conjugated diene product formation using arachidonic acid by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed