BDBM50351019 CHEMBL1819180

SMILES C(CCCNc1c2Cc3ccccc3-c2nc2ccccc12)CCCNc1c2Cc3ccccc3-c2nc2ccccc12

InChI Key InChIKey=NQXQNWAFOUTKOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50351019   

TargetBeta-secretase 1(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 400nMAssay Description:Inhibition of BACE1 expressed in baculovirus assessed as inhibition of amyloid beta-42 production after 60 mins by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 455nMAssay Description:Mixed-type inhibition of human AChE assessed as hydrolysis of acetylthiocholine by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50351019(CHEMBL1819180)
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed