BDBM50352760 CHEMBL1823221::US9126931, 350

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(CC1)C1COC1

InChI Key InChIKey=XDTMZEAHVJVNJG-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50352760   

TargetFibroblast growth factor receptor 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FGFR2 activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR using Bio-Gastrintide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KIT using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MET using Bio-HER2tide as substrate by TR-FRET assay in presence of 50 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDR activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KIT activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MET activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRC activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 7.15nMAssay Description:ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HER2 activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AKT1 activity by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Aurora-A activity by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCb2 activity by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Raf-1 activity assessed as MEK1/2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCA activity by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 460nMAssay Description:Inhibition of INSR activity by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCb2 activity by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed