BDBM50353432 CHEMBL1829876::US10196373, Compound 45O
SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
InChI Key InChIKey=WNVSFFVDMUSXSX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50353432
TargetSignal transducer and activator of transcription 3(Mouse)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of STAT3 in mouse NIH3T3/vSrc nuclear extract assessed as disruption of the Stat3-DNA complex pre-incubated for 30 mins by EMSA analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 2.56E+4nMAssay Description:Competitive binding affinity to Stat3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Binding affinity to Stat3 (unknown origin) using hSIE as probe preincubated for 30 mins followed by hSIE addition by electrophoretic mobility shift a...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Mouse)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 DNA binding activity in mouse NIH/3T3 nuclear extract preincubated for 30 mins followed by [32P]hSIE addition measured after 30 m...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 (unknown origin) binding to DNA by EMSA analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKd: 4.57E+3nMAssay Description:Binding affinity to His-tagged STAT3 (127 to 722 residues) (unknown origin) incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKd: 500nMAssay Description:Binding affinity to full length STAT3 (unknown origin) by Surface plasmon resonanceMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKd: 504nMAssay Description:Binding affinity to STAT3 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKd: 504nMAssay Description:Binding affinity to STAT3 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of STAT3 (unknown origin) DNA binding activity by EMSAMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKi: 1.28E+4nMAssay Description:Inhibition of STAT3 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 15 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Human)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair