BDBM50353675 CHEMBL1830335

SMILES CC(C)c1ccc(OC(=O)CCc2cc(-c3ccc(C)cc3)n(n2)-c2ccc(Cl)nn2)cc1

InChI Key InChIKey=QRHFTBCKZSVPIH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50353675   

TargetProstaglandin G/H synthase 1(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50353675(CHEMBL1830335)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50353675(CHEMBL1830335)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50353675(CHEMBL1830335)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX2-mediated 6-keto PGF1alpha production in IL1-beta stimulated human A549 cells after 10 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50353675(CHEMBL1830335)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 12-Lipoxygenase-mediated 12-HETE in human neutrophil after 15 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50353675(CHEMBL1830335)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed