BDBM50353854 CHEMBL1831165::US9604926, Compound CM-350::US9724435, Compound CM-350

SMILES Fc1ccc(cc1)N1CCN(CCCCn2cc(-c3ccc(F)cc3)c3ccccc23)CC1

InChI Key InChIKey=CMLNSXADDBXCGP-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50353854   

TargetSigma intracellular receptor 2(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353854(CHEMBL1831165 | US9604926, Compound CM-350 | US972...)
Affinity DataKi:  83.3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
The University of Mississippi

US Patent
LigandPNGBDBM50353854(CHEMBL1831165 | US9604926, Compound CM-350 | US972...)
Affinity DataKi:  83.3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353854(CHEMBL1831165 | US9604926, Compound CM-350 | US972...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353854(CHEMBL1831165 | US9604926, Compound CM-350 | US972...)
Affinity DataKi:  1.20E+3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353854(CHEMBL1831165 | US9604926, Compound CM-350 | US972...)
Affinity DataKi:  1.20E+3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent