BDBM50354894 CHEMBL1837037

SMILES CN1Cc2nnc(C3CCN(CC3)c3ccccn3)n2-c2ccc(Cl)cc2C1

InChI Key InChIKey=LXHAZNJVVVBJIF-UHFFFAOYSA-N

Data  1 KI  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50354894   

TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataEC50:  265nMAssay Description:Agonist activity at human V2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 8.49E+3nMAssay Description:Antagonist activity at human V2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 1.79E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataIC50: 31nMAssay Description:Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354894(CHEMBL1837037)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed