BDBM50355465 CHEMBL1835741

SMILES COc1ccccc1Nc1nc(N)n(n1)-c1ccccn1

InChI Key InChIKey=FELCCLMGXTVEGI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50355465   

TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355465(CHEMBL1835741)
Affinity DataKi:  12nMAssay Description:Displacement of [33P]ATP from human recombinant c-KIT domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355465(CHEMBL1835741)
Affinity DataKi:  15nMAssay Description:Displacement of [33P]ATP from human recombinant FLT3 domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355465(CHEMBL1835741)
Affinity DataKi:  420nMAssay Description:Inhibition of IRAK4 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355465(CHEMBL1835741)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355465(CHEMBL1835741)
Affinity DataKi: >7.00E+3nMAssay Description:Inhibition of Aurora A by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed