BDBM50357098 CHEMBL1917245

SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CSc1nc2ccccc2s1

InChI Key InChIKey=APMXINIHAJAOIT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50357098   

TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50357098(CHEMBL1917245)
Affinity DataIC50: 4.40nMAssay Description:Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50357098(CHEMBL1917245)
Affinity DataIC50: 18nMAssay Description:Inhibition of human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50357098(CHEMBL1917245)
Affinity DataEC50:  45.5nMAssay Description:Transactivation activity at glucocorticoid receptor in human HepG2 cells expressing luciferase-taggged GRE gene by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed