BDBM50357877 CHEMBL1916137

SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC(F)(F)F)cc21

InChI Key InChIKey=XCTJCGBYOUBBCH-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357877   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357877(CHEMBL1916137)Copy SMILESCopy InChI

Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy BDB DOIPubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357877(CHEMBL1916137)Copy SMILESCopy InChI

Affinity DataIC50: 128nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL