BDBM50360514 (E)-1-(2,4-dihydroxyphenyl)-3-(2-chlorophenyl)-2-propen-1-one (6)::CHEMBL1935203

SMILES Oc1ccc(C(=O)\C=C\c2ccccc2Cl)c(O)c1

InChI Key InChIKey=HUJPOSGMEWSBGX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50360514   

TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM50360514(CHEMBL1935203 | (E)-1-(2,4-dihydroxyphenyl)-3-(2-c...)
Affinity DataIC50: 1.14E+4nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed
LigandPNGBDBM50360514(CHEMBL1935203 | (E)-1-(2,4-dihydroxyphenyl)-3-(2-c...)
Affinity DataIC50: 3.28E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50360514(CHEMBL1935203 | (E)-1-(2,4-dihydroxyphenyl)-3-(2-c...)
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by FluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50360514(CHEMBL1935203 | (E)-1-(2,4-dihydroxyphenyl)-3-(2-c...)
Affinity DataIC50: 320nMAssay Description:Inhibition of HIV1 His6-tagged integrase-human GST tagged LEDGF/p75 (373-442 residues) interaction after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed