BDBM50361164 CHEMBL4174188

SMILES Clc1ccc(CN2CCN3C(C2)C(=O)N(OC(=O)N2CCOc4ccccc24)C3=O)cc1

InChI Key InChIKey=OZPZCETZTBBQBO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50361164   

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 89nMAssay Description:Inhibition of NOTUM in human SW620 cells conditioned medium assessed as preservation of Wnt3A activity pretreated for 1 hr followed by Wnt3A producin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 13nMAssay Description:Inhibition of rhodamine-tagged FP probe binding to NOTUM in human SW620 cells conditioned media pretreated for 30 mins followed by rhodamine-tagged F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 170nMAssay Description:Covalent inhibition of human Notum (S81-T451 residues) C330S mutant expressed in HEK293S cells using OPTS substrate incubated for 40 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 170nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50361164(CHEMBL4174188)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant Notum (81 to T451 residues) expressed in HEK293S cells using OPTS as substrate incubated for 40 mins by microplate re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed