BDBM50361635 CHEMBL1939878::US8785489, ethyl 5-{5-methyl-2-[(pyridin-4-ylmethyl)carbamoyl]pyridin-4-yl}-1H-indole-2-carboxylate

SMILES CCOC(=O)c1cc2cc(ccc2[nH]1)-c1cc(ncc1C)C(=O)NCc1ccncc1

InChI Key InChIKey=DMKUTALHEIQGEX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50361635   

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCollagenase 3(Mouse)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: 155nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetCollagenase 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: 640nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed