BDBM50362951 CHEMBL1946568

SMILES C[C@@H](Oc1cc(Cn2c3cc(ccc3n(-c3ccc(cc3)C(C)(C)C)c2=O)C(F)(F)F)ccc1Cl)C(O)=O

InChI Key InChIKey=OKAPTEQUUMALED-UHFFFAOYSA-N

Data  3 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50362951   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50: >5.00E+4nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of Src-1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50:  440nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PBP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataIC50: 161nMAssay Description:Binding affinity to human PPARgamma by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50:  480nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of CBP1-453 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50:  135nMAssay Description:Agonist activity at human PPARgamma expressed in COS-1 cells co-expressing with Gal4 by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human PPARalpha expressed in COS-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataEC50:  460nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362951(CHEMBL1946568)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed