BDBM50363447 CHEMBL1946325

SMILES COc1ccc(cc1)Nc2ncc3c(n2)n(c(n3)Nc4ccccc4F)C5CCCC5

InChI Key InChIKey=IMFVPVKPQOQCBY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50363447   

TargetMitogen-activated protein kinase 8(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50363447(CHEMBL1946325)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full length Hexa-His-tagged JNK1 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50363447(CHEMBL1946325)
Affinity DataIC50: 120nMAssay Description:Inhibition of full length Hexa-His-tagged JNK2 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50363447(CHEMBL1946325)
Affinity DataIC50: 210nMAssay Description:Inhibition of full length Hexa-His-tagged JNK3 using GST-tagged cJun and [gamma33P]ATP as substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50363447(CHEMBL1946325)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of p38alpha using MBP and [gamma33P]ATP as substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed