BDBM50363953 CHEMBL1951778::CHEMBL1963131

SMILES COc1ccc(cn1)[C@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=NXZNYBUBXWWKCP-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50363953   

TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC after 30 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 30nMAssay Description:Displacement of dofetidine from human ErgMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human CCR2-mediated Erk phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CCR2-mediated intracellular calcium mobilization by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of human Erg by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50363953(CHEMBL1951778 | CHEMBL1963131)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed