BDBM50365534 CHEMBL1957652

SMILES Cc1csc(n1)-c1[nH]c(CN)nc1-c1ccc2OCOc2c1

InChI Key InChIKey=MBTAXWYDKFCVAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50365534   

TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365534(CHEMBL1957652)
Affinity DataIC50: 790nMAssay Description:Inhibition of human recombinant GST-fused ALK5 using TMB substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365534(CHEMBL1957652)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant ALK5 activity in human A549 cells assessed as TGFbeta-induced smad2/3 phosphorylation after 2 hrs by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed