BDBM50369047 CHEMBL4175680

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(cs2)-c2cccnc2OCCCc2ccccc2)cc1

InChI Key InChIKey=MUYWYPLCIQMGOJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50369047   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369047(CHEMBL4175680)
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369047(CHEMBL4175680)
Affinity DataIC50: 3.30E+3nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed