BDBM50370181 CHEMBL4159382::US11117865, Compound ZL0454

SMILES Cc1cc(\N=N\c2ccc(cc2)S(=O)(=O)NC2CCCC2)c(N)cc1O

InChI Key InChIKey=IRKMSULWLDLTIK-UHFFFAOYSA-N

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50370181   

TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to BRD2-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 32nMAssay Description:Binding affinity to BRD4-BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 32nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 38nMAssay Description:Inhibition of his9-tagged BRD2-BD2 (unknown origin) preincubated for 30 mins followed by addition of biotinylated peptide and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 49nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 49nMAssay Description:Binding affinity to BRD4-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 49nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 730nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 772nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 772nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 790nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 810nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 860nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human his tagged BRD4-BD2 using Histone H4 peptide (1-21) K5/8/12/16Ac as substrate preincubated for 30 mins followed by addition of bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of his9-tagged BRD4-BD1 (unknown origin) preincubated for 30 mins followed by addition of biotinylated peptide and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.84E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 2.24E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 2.49E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 3.08E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 3.29E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 3.29E+3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50370181BDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent