BDBM50370182 CHEMBL4176038::US11117865, Compound ZL0420

SMILES Cc1cc(\N=N\c2ccc3NC(=O)CCc3c2)c(N)cc1O

InChI Key InChIKey=ANMQADUROYWADA-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50370182   

TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 32nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 27nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.78E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 3.18E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.19E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.28E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 1.74E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 803nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
University Of Texas

US Patent
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 490nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 803nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 530nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 27nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 580nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370182(CHEMBL4176038 | US11117865, Compound ZL0420)
Affinity DataIC50: 510nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed