BDBM50370518 CHEMBL4176474::US10954217, Example 00229

SMILES O=C(OCc1ccccc1)N1Cc2ccc(cc2C1)N1CCN(CC1)C1CCCC1

InChI Key InChIKey=FUWNTUBEOVLTGS-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50370518   

TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  8.20nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  44nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  165nMAssay Description:Displacement of [3H]-alpha-methylhistamine from human histamine H3 receptor expressed in HEK Flp-In cells after 90 mins by microbeta scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  594nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [125I]-iodoaminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370518(CHEMBL4176474 | US10954217, Example 00229)
Affinity DataKi:  2.14E+3nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed